TXA

Written By The Administrator

For trauma? 

  • CRASH 2: Saves lives 

  • It’s cheap, easy, and comes with very little risk 

  • The risk gets smaller and smaller the earlier you administer it in trauma , only administer if injury occurred within 3 hours of hospital presentation

  • 1g bolus given over 10 minutes, followed by 1g over 8hrs, 

For TBI?

  • Traumatic extracranial hemorrhage as well as TBI we can go ahead and give the TXA 

  • But for those with isolated head injury, the evidence is not a clear yes (CRASH 3)

For PPH? 

  • Yes under current ACOG guidelines (WOMAN trial)

For epistaxis? 

  • In the highest quality trial to date, there was absolutely no value in using topical TXA in the management of epistaxis (NoPAC). 

For angioedema? 

  • Limited data has not shown any benefit 

For GI bleed?

  •  In the highest quality trial to date, there was absolutely no value in using TXA in the management of GI bleed, with actually an increase in adverse events (HALT-IT)


The Administrator
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